My favorite has to be Nuendo right now...I was a cakewalk user when I first started and quickly realized it's limitaions..no direct monitoring of fx, terrible EQing ability and lack of a good mixing view. Then I found Cubase and was creating more happily than ever..I enjoyed the interface, the ability to choose what type of monitoring I wanted, the clear menu selections on sync and MIDI. I tried Logic at one point but found myself having to really read the manual many times over to understand certain aspects of it..the mixer was nice but the environment made it impossible to get things done quickly if you didnt know what the hell was going on with it. Then came Nuendo...wow!! a complete step up from Cubase and a pretty good contender to Pro Tools..I never really got into Pro Tools since it requires 20 plus grand to even get started on a real Pro Tools system...dont have that type of cash lying around!! Anyways, Nuendo has a rock solid feel and style to it. Brings out the creativity in me that I like.
In the long run most people are right when they say it's totally up to you and how you learn and adapt to a certain interface. One can say all they want about a certain software but in the end "you" have to be happy!