1) Purpose built and designed desktops or rackmount pc's with PCI/PCIe buses tend to have the lowest latencies levels. Low latency and sample buffers are highly desirable for voice over work or punching into mixes. That said, I mostly run laptops these days with 1394b firwire connections with very happy results.
2) Keeping a computer completely offline means you really don't require firewire/antivirus/anti spyware software installed. This streamlines things a great deal. Most full time pro recording computers whether desktop or laptop do NOT have antivirus software. The catch is that it is up to you to be aware that every flash drive, thumb drive, aux hard drive may or may not contain viruses so your main computer should be scanning these regularly. It's like safe ***, know where you've dipped your wick.
3) The best machines are built by audio companies or home built with great pieces. The best place to look at specs is the digidesign website even if you don't intend to use ProTools. I use Dells when I buy off the shelf but the in built latency varies greatly from model to model. If possible check it out with DPC Latency Checker before you buy.
4) Vista Business or Ultimate is just fine. Joe Hannigan just posted some good tips regarding permissions in an earlier thread. I've used Vista Ultimate highly successfully myself. That said, if you wait until Win7 is released, I really like it.


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