I believe the issue is one that no one has yet picked up on in the thread. You mention that you are routing the Direct Outs of channels from your mixer to your interface. Therein lies the issue. The Direct Outs are exactly that. They are the signal After the Mic Pre, but before any other processing on the mixer. So no reverb, no EQ ,etc. They also are not panned as they are just a mono signal, thus why you are not getting panning in your computer software. You need to set the panning for the output of the channels in the software. To get reverb, EQ, etc. on the channels you are sending, you are going to have to route the Main Stereo Outs (or whatever B***hringer calls them) or Sub Groups (if this mixer has them) out. That, of course, means that all channels routed to the Stereo Outs will also already be mixed together. The most you could do would be to do two channels at a time, panning one to the Left and the other to the Right.
Hope this helps. Have fun!