I would use the SSD as the main drive for the OS and programs. Put it on an onboard SATA2 connection. Put the audio drives on onboard SATA3 connectors. One drive for recording sessions and one drive for samples and virtual instruments. Incidentally, for recording sessions I use a maximum of 500GB drives because of the better reliability factor as well as speed. I archive the finished audio sessions on larger drives. Use the other headers for blu ray burner and even more drives. You can also get headers to run eSATA connections which is great for long term storage.