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New equipment, trying to figure out best signal flow approac

Greetings! I'm trying to figure out what would be the best setup for the following gear. . There's probably several different ways one could go about doing this, and I've started but have a few questions.. I'm kind of new to all of this but recently had the opportunity to design a small studio for a non-profit. If anyone could help with a diagram or some advice I'd really appreciate it..

Help! Macintosh won't take M-Audio Quattro signal!

I'm an amateur trying to do something very simple and very necessary and failing to get off the ground.

I've got a Power Mac G5 running OS X Tiger (recent upgrade from Panther) and Garage Band. I blew 100 bucks on an M-Audio Quattro to convert my guitar signal from a jack to USB signal. I can't get any guitar signal into my Mac at all. Nothing.