I just upgraded my mixing/mastering DAW to a Quadcore with 8GB RAM, Nuendo and vista64 and XP64 (got connections at work 8) ) and to my frustration found out that there are only old crappy XP64 beta drivers for my delta, that don't even work (at least not in my case... nice work M-Audio! you suck! :evil: ). So now I need a low latency interface with two analog outputs , one or two analog inputs and a perfect driver support with Vista64 and XP64, and it wouldn't hurt to have a RCA S/PDIF too, but it's not nessesary. PCI, PCIe, USB and FireWire all work for me. I don't need a preamp or monitor control as I already have that in seperate units.