I have a fairly advanced MOTU setup that I been working with since last year, and it's been frustrating to feel so close, yet so far, from mixes that sparkle. After much lurking, theorizing, and some experimentation (which was helpful in confirming what wasn't working), I sprang for a midas venice console and WOW! What a difference! With the Venice, I can find and tweak EQ settings that are just too elusive via the mouse. Plus, the EQ sounds so much better (compared with MOTU's EQ; n.b. I haven't tried the Cambridge plugin for my UAD-1 yet). Now, I'm not a trained mixing engineer, and perhaps in a year or so I will learn so much about EQ from the board that I'll be able to dial in the perfect amounts from my DAW. But until then I just have to say that having a real board, with real knobs, and really good sounding EQ, is definitely going to take me places that I couldn't get to with my mouse. But here's the bottom line: routing from MOTU -> Midas -> MOTU is giving me better sound than I could ever get just staying in the digital domain. Go figure!