I just bought a Saffire 6 USB. As some might recall, I had made several posts related to interfaces some time ago. I actually bought the Saffire Pro 14, in order to get up to 96Khz sampling, but the Firewire was a disaster, with tons of dropouts and random digititis, so I exchanged it for the USB 6. There was conflicting information from Focusrite as to whether the Pro 14 was Vista 64 bit compatible (both on the website and in the literature) but I can report problems, and would say it is not compatible. In any event I have had the Saffire 6 USB up and running now for a few hours. What a remarkable relief to have a reliable interface. It may only go up to 44.1 or 48Khz, but I cannot believe how much more easily one can work when the system is stable. As far as sound, it thoroughly crushes the Firebox I had (for the brief occasions that it worked) in every way. It is extremely quiet and noise free. It is simple to use, and I like it.