Here is an interesting one... I got my Fireface up and running with Cubase SX3 on my laptop (Vaio) with no problems. I recorded a concert last night with no problems and it sounds great! I have the same setup with my studio PC, but whenever I open Cubase I get a small bit of digital distortion through the phone monitor (chan 9/10) when Cubase tries to latch onto the Fireface. I have no playback meters or audio in TotalMix or Cubase, except when I get the initial distort on loading. No glory in Sound Forge either, so it seems to be on the RME side of things. I have checked all the prefs and VST connections on both machines and they appear to be set up identical. The Fireface has the 2.4 driver and firmware update. The only difference I can tell is the laptop uses a 800 (9 pin) to 400 (4 pin) firewire cable and I am going 800 to 800 cable with the desktop. I am going to try either a 9 to 6 pin or 6 to 6 pin cable to see if that kills the distortion and no playback issue. It would be nice to actually use the 800 side though! I read the tech updates on RME's site, but am wary about getting another PCI card. According to my card specs, it should be ok. Have any of you run into this problem? Was there another solution? Thanks so much for any help! I highly recommend this interface! It sounds amazing. Even the seasoned house crew at the concert venue were inpressed with my, "28 track studio in a carry-on bag"!