I went ahead and got a Nforce 4 SLI based Gigabyte GA-K8N Pro-SLI(not specifically recommended on forums but it was available right by my work). After popping in my X2 4400, 2 gigs, AudioPhile 192, and getting Cubase SX 3 going, I got pops and cracks upon loading a project that previously was fine on my Nforce 3 (that recently went up in smoke). This was using 256 latency. The load was not that heavy, as I had 2 iterations of Trash, 6 Amplitube's, 10 C1's and a few C4's over 20 odd tracks So trust my luck, I ran into the same issues everyone has complained about. I am keeping my 4400, AP192, and dual raptors in raid-0, but all other suggestions for a trouble free mobo/memory combo are welcome. Cost is not an issue, barring a Tyan with dual dual Opterons of course. Specifically if anyone has tested ATI's newest offering, the Xpress 200, I would be interested to hear about that. Dorism over in the Cakewalk forums tested an Xpress system with a 4400 and a M-audio 1010LT with very good results on the S3 Sonar test. dorism: "Bought a new PC from http://www.cube247.com...PC cost just over £1000 for this spec! AMD Athlon 64 X2 4400 ATI Radeon xpress 200 Windows XPSP2 2Gig RAM M-Audio 1010LT (WDM driver) 2x250Gb Baracuda drives (SATA) Quiet PSU Results are really impressive 46.4ms 10% 23.2ms 15% 11.6ms 21% 5.8ms 26% 2.9ms 37% 1.5ms 55% "