Ignoring for a moment the balanced/unbalanced problem, if you wire the output of the external Neve pre-amp to the SL's insert return point, the SL will continue to route and function exactly as before, except that now that channel will be handling a mic or line signal from a different input device (the Neve). When connected this way, if you are tracking via the SL's FW interface to a DAW, then the SL is acting purely as an A-D converter, like a line-level audio interface.I'm thinking once I bypass the onboard pre (insert a Neve pre) this also disconnects the rest of that channel going through FW to the DAW (SL Capture software).
The unbalanced nature of single-jack insert returns can be a problem when you are trying to feed them with quality pre-amps. We've had threads on this before, but basically you have a balancing problem and a level problem. Assuming the pre-amp has independent drivers for its + and - outputs, you need to use a cable wired to take the + signal from from the pre-amp's output jack or XLR to the ring connection of the mixer's TRS insert jack plug in order to carry an unbalanced signal into the mixer. However, top-range pre-amps tend to have either electronically-balanced or transformer-coupled outputs, and these need different wiring to take the output to the ring and sleeve (ground) of the TRS insert jack. Note that in both cases the tip contact of the insert TRS plug is left unconnected, as this is the send signal, i.e. the output of the mixer's internal pre-amp.
The nominal level at unbalanced insert returns is usually -2dBu, this being the 6dB reduction from +4dBu through loss of half the signal. Full-scale (FS) levels are typically 18dB higher than this. The -2dBu nominal figure can be an acceptable match to the output of many mid-range pre-amps when just a + output is taken. However, with electronically balanced or transformer-coupled outputs, not only will both of these will deliver the pre-amp's full range output into a balanced or an unbalanced load, but it's a frequent production requirement to drive these pre-amps into slight overload to take advantage of the sound of transformer saturation. In this case, you may be presenting something like a +32dBu peak signal to an insert point that has only 18dB headroom above a nominal level of -2dBu, i.e. +16dBuFS. It's time to reach for the in-line attenuators...