Hey Fats - Might as well get this ball at least rolling, if not bouncing :=)
I've been using Samplitude for about 5-6 years now, synced to Cakewalk for MIDI. Samp doesn't do MIDI except for being able to sync to it, until the last version or two, and even those versions aren't powerful enough in MIDI to be taken seriously. Maybe version 7... (due out right about now)
For digital audio, I've yet to find anything that can even stay in the same room with Samp without hanging its head in shame - tried a demo of cubase about a year ago, what a POS. Unfriendly as hell, can't do half the stuff even WITH the manual in front of you - gave up and wiped it. Tried Minnetonka, liked the "build yer own mixer " idea, but saw nothing to cause me to jump ship. Cake up to V9 still hadn't found out how to do audio (too klunky, can't tell what you're doing, record levels kinda hit or miss) Sound Forge (I have 4.5) is great, but not multitrack and no MIDI. They make you pay extra for NR, which works pretty good.
Samp has had a super sounding summing algorithm since I've been using it - even with 20 bit hardware, it just sounds like what went in, even with 20 stereo tracks. I've always used 32 float/44.1 - Samp has had that for several years, even saves projects to disk that way, and the only time you deviate is when you burn a CD or monitor. Then, hardware limitations kick in.
Samp is pretty intuitive, I've RARELY had to hit the help files in order to figure out how to do something. Usually, you just click on a menu item and follow the dialog boxes. Lotsa quick 1-key macros standard, and you can make your own for oft-used operations. One of the standard macro's is M (brings up the virtual mixer - pretty hard to remember, huh? Another is O - brings up the Open Project dialog - duh... R for Record, space bar toggles play, etc -
Also, a lot of what the other guys make you pay for, is included in Samp, like noise reduction, multi-band compression, FFT analysis, etc.
I might have tried ProTools had I been born rich, but since I don't work for Geffen or Skywalker, I found I couldn't justify the cost for what you got. Turns out I may have been lucky in a way, heard a lotta crap about Alsihad that I've NEVER felt about Samplitude. In all fairness, I've not actually HEARD Alsihad except in final products...
Samp responds to as many as 16 different MIDI controllers PER TRACK, and has a "LEARN" mode, so works pretty well with just about any control surface. So far, it's a little light on MMC, as are most proggies to date.
One thing I really like is the project notes file that can be set to pop up every time you open a project - Basically just a word processor that you can blab as much info into as you like. Great for all the notes you thought you knew where the file folder was...
Probably missed a ton of other reasons, just woke up after 6 12-hour graveyard shifts so probably won't be even semi-cognizant til tomorrow.
Soooo, Samplitude's my drug of choice, you won't be able to pry it from my cold, dead fingers; you'll hafta bring a bone saw... Steve