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Suddenly my Mac became very slow when plugging in Mackie Onyx 1220i

I've run my mac with the Mackie Onyx 1220i for the last two days, and it have worked very well. Then I started Logic Pro 9 and it was very slow. After a restart, the whole machine was still slow. I unplugged the mixer and everything was back to normal. What is wrong?

Makcie Onyx 1220i with Ableton Live!

So I am using a Mackie 1220i hooked up to my PC via firewire to Ableton live.

My question in brief is how do I mutlitrack? Here is more details;

When I select my audio input devices in Ableton I see 8 Mackie drivers:

Mackie CH 1-2, 3-4 and so on.
The Mackie CH 13-14 are Aux sends and 15-16 are master.
Ableton only lets me choose 1 driver at a time.

Help connecting m-audio profire lightbridge and onyx 800r

Hi there guys, i really need some help, this is my first attempt at going fully digital, my previous setup was anoolog outs from my 2 Mackie onyx 800r units into delta 1010 pci soundcards. i have now bought a M-audio Profire Lightbridge and need help syncing everything as i am pretty new to all this.