I really like Nuendo! I used Samplitude 2496 for years until I tried Nuendo. I still use Samplitude for CD layout & burning but that's about it I use Nuendo for audio & midi recording, editing, mixing & Mastering. I now do all mixing internally within the DAW with absolute confidence. Using ASIO 2 drivers (very low latency) I can have many (over 24) tracks playing without any "sluggishness". And I just began using the Native VST instruments, which are VERY cool! Pentium III 933/500mb I use the UA PP Card with very nice results. It frees up lots more DSP horsepower for mixing & editing. I use a MOTU 2408 as an I/O. I use the Tascam US-428 as a control surface. It works well (I'm waiting to test drive the Houston) For the money, you just can't go wrong with this setup.