I'm pretty much in agreement with Dan Thompson's ( no relation, LOL) remarks on the video below.
Personally, I use them more for analytical referencing; checking for too much effect on certain tracks, panning, space and separation, listening for things like a short/cut fade, clicks or pops, etc.
When I was 19, I had ear surgery - both ears - to remove some cartilage that was growing towards my ear drums. While the surgery fixed everything fine, to this day, I still feel physical pain on the outer shell of my ears if they are compressed for too long, such as sleeping on them, or, using headphones... basically, anything that presses against my ears for too long can result in some pretty serious physical discomfort, so this really does limit the amount of time I can wear HP's.
As a rule, I don't mix with headphones, but I do use them as a valuable tool from time to time, for short periods.