What's your budget? How many channels do you need with what mix of microphone and instrument inputs? Do you want a live sound mixer from which you can only record the 2-track mix, or an audio interface that records each track separately for later mixdown? Are you restricted to USB, or does your computer have either a native FireWire port or an expansion slot for a plug-in FireWire interface card?

Mackie all the way :) you'll be able to use it for other things too and have a great mixer for whatever your needs are.

The Mackie ProFX series is not a multichannel interface. It is a two channel stereo bus interface. The Mackie multichannel interfaces are the Onyx mixers and the Blackbird.

I have an RME fireface UC, they are very expensive, but amazing for all kinds of reasons! Check it out

Also, I had an edirol ua-101 before, which was a 10 in 10 out USB 2 interface, I really liked the pre's on it, but it died on me a few months back.

And then cheaper still is the focusrite saffire USB 6, which is a 2 in 4 out usb interface, which is quite nice and not very expensive

Good luck

I have the Saffire 6 USB. I have only brief experience with two other Firewire interfaces, so take my remarks with that limitation in place, but I am very happy with it. It is stable, easy to operate, and I think it sounds good.