I would get a larger power supply to reduce the percentage of load. PSU's are cheap these days. Get many large fans. Large fans move more air at lower RPM's and hence are quieter. One desktop I built a couple of years ago for a client had a 120mm main fan and three 80mm fans. None of them ever had to spin fast. Of course I had to cut a few custom holes in the case but nothing a knock out from Greenlee can't handle. I haven't read any reviews of the Z68 mobo. I'm cut off from civilization out here in the summer which explains the rarity of my posts May-Sept. Don't get overly excited by USB 3 or SATA 6gb. It doesn't suck. It is just that the new light format will be hitting end users probably this fall or winter. If you can hold off on your build for six months you might have a different component list. At least do some reading on Thunderbolt (which will have adapters for SATA/1394/USB etc).

Thanks for the feedback. I am looking into a larger power supply and additional fans. The mics are in their own studio away from the CPU, so I don't mind a little CPU hum as it is no where near the studio. The CPU will be used for voice over work/radio/narration/audiobook work only (no music applications).

Power supplies are a very important component. What brand of power supply are you looking at? You might consider an Antec or Thermaltake brand. The Z68 chipset is designed to combine a Solid State Hard drive with a traditional drive and the operating system can use them as one drive. You can add a SSD for $100-$300+ depending on size and speed. Also, get 16 GB of ram. Don't get a 3 GB/sec drive either. A 6 GB/sec drive will be backwards compatible and should cost the same. You dont need to spend the extra money on the 2500K chip unless you plan on overclocking it. Just get the 2500.