EQing samples -- is there a method to this madness?

I've just started using Kontakt for MIDIs. In regard to the samples it comes with, how should I treat them when mixing?

Do they need the same EQ treatment as normal audio files? In other words, should I treat my Kontakt sample bass guitar as if it were any other audio track-recorded bass guitar?

And the drums seem to be panned already -- at least the toms -- they seem to "sweep across from about 10 o'clock to about 3 o'clock.

Any guidance would be most sincerely appreciated.