or... Here's what I've read:

digital AES/EBU connections sound relatively thin in the midrange.
AES/EBU sound better
AES/EBU has more bandwidth.
BNC or true 75 ohm RCA connectors is a significant upgrade if you use the coax connection.
aes should introduce less jitter than S/PDIF under most circumstances
AES and SPDIF have no inherent sonic differences. They only differ by their metADATa and binary voltages
S/DIF interface was clearly superior to all others

I have no idea but I'm interested what the choice for 16 digital IO