I would hesitate to add anything of any sort to a reamped track going out to the amp. You're gonna want to get the best signal you can and let the amps' magic happen. You're going to print this track anyway and thats where I would apply any necessary compression or signal alteration if needed.

The sound of the amp itself is going to be somewhat compressed as it is....tubes and iron and speakers and all.....

I see that as largely unnecessary; sure, it would smooth out things a tiny, tiny bit, but couldn't you do that just as easily (if you wanted to) after it's reamped? Electric guitars really can't get obnoxious peaks like drums, bass, and vox can when going through an amp. I will admit that I put a very, very, very, very slight limiter on everything including electric guitar just to make sure I'm not going to even slighty clip at any point, but this is to facilitate loudness and not pristine audio quality.

I've done it before. It's kind of cool to have sick levels of sustain pouring out of a guitar amp.

Try it each way and see what you think. That's the whole beauty of reamping.