How would a Focusrite saffire measure up to a PreSonus firebox, or an m-audio 1814.. would it be a very noticeable difference?

I want a soundcard of pro quality, good preamp gain and clarity in a firewire form factor..

Also, I was thinking of just saving for a Mackie Onyx 1220, along with the optional firewire card..
what do you guys think?

thanks a lot.