If your DAW can route multiple aux sends or submixes to the outputs then yes.
However, you'll need four separate HP amplifiers.

bent wrote: If your DAW can route multiple aux sends or submixes to the outputs then yes.
However, you'll need four separate HP amplifiers.

I'm using Logic Pro 8. How do the HP amps connect to the interface?

I do not own a Firestudio, but I'm thinking this would be your best bet:

From the manual:
General Purpose Outputs: These stereo TRS balanced outputs can be used for
any purpose, and derive their output signal from your DAW, the FIRESTUDIO
Control Console software, or the optional MSR remote. There are no level
attenuators on the FIRESTUDIO for these outputs.

bent wrote: I do not own a Firestudio, but I'm thinking this would be your best bet:

From the manual:
General Purpose Outputs: These stereo TRS balanced outputs can be used for
any purpose, and derive their output signal from your DAW, the FIRESTUDIO
Control Console software, or the optional MSR remote. There are no level
attenuators on the FIRESTUDIO for these outputs.

Thanks