Here are features Sequoia has that Samplitude doesn't:

In addition to everything Samplitude Pro X Suites has…

Sequoia also contains:

• - Advanced Xfade editor
• - DDP export, DDP Player, and editor
• - Automatic normalization function (float) before CD export
• - Source Destination Cut
• - Multi-synchronous Cut (Musyc), Find Audio
• - Broadcast integration - content management systems
• - User administration/multi users accounts
• - Macros
• - VCA faders in the mixer
• - Auto Ducking Automation
• - Video recording, basic editing and video export
• - Cleaning and restoration suite is included and built in to Sequoia ($200 extra for Samplitude)
• - Spectral Cleaning Editor with highly advanced functions (Harmonics, individual editing on multi-track material...)
• - Independence Pro with full library
• - Surround : Samplitude is only 5.1, Sequoia is 5.1 and 7.1 and beyond up to 12.0
• - R 128: loudness metering, batch processing, watch folder, calculation of projects and files, loudness XML report
• - True Peak Limiter in sMax11 (to avoid intersample peaks)
• - Maintenance contract available
• - Sequoia can sync to SMPTE, Samplitude only to MTC or via the SMPTE option (TCO) from RME
• - Timecode Track
• - ISRC in broadcast wave files compliant with EBU Tech 3352 (for export, CD-import, display in VIP)
• - Export while recording