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Bypassing the mixer preamps

Hi, I know this has been discussed here before so I ask for your indulgence. I'm trying to a Mackie 12 channel mixer as a patchbay- plugging my Avalon m5, API, Focusrite, Neve Portico and maybe an old Joemeek down to two inputs into my OO2.
I've read about someone, maybe Kurt bypassing the preamps in his Mackie when heading ito his DAW,
Am I on the wrong track?

Bypassing pres on Digi 002

I read that if you have a better mic preamp than the ones in the 002 you can use the optical ins/outs so that you can bypass the pre in the 002. My question is this: What if I need my sampler to be in sync with my 002 (drums, etc)? Will I have to switch every time or is there a less complicated way than this?

TIA and have a great weekend