I'm running a Pro Tools Mix 24 Plus system thru a pair of Apogee AD8000SEs and have been using an 02R just for monitoring. I've just reconfigured the system by adding ADAT Lightpipe cards to each Apogee and bringing 16 digital channels back into the tape inputs of the 02R via ADAT cards.

Alright I just bought Nuendo and the Hammerfall/Nuendo card, along with an O2R ver 2 with 2 ADAT cards for hooking into it!