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Cubase 4 le please help

Right I'm new to Cubase and computer recording, my sey up is my pc to a Tascam 1641 interface ive pretty much got everything sorted but theres a few things i cant seem to figure out,

Problem 1: at random times ill be playing or recording a song and my speakers will start to make a weird weak distorted sound then after a while will return to normall.