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Reasonable System Upgrade

Has anyone upgraded their systems to a board or OS that supports 64bit processors such as the Pentium D and had any problems or luck with Nuendo or Cubase SX, Reason, and effects/vst plugins, etc.? We're considering upgrading our system. Right now, we have a Pentium 4 2.4ghz processor which when the ONYX 1220 mixer is turned on takes about 50% in resources (and no there are no other tasks).