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Difference Between Mic Line and Instrument Channels

Hey,
I've got a question about every interface I see. They all seem to have both Mic Inputs (XLR) and instrument inputs (1/4 In.) Whats the difference between them? For example. I've got a Firepod with 8 inputs. 1-2 are instrument/mic, 3-8 are mic line ins. They all have XLR / 1/4in jacks so why can't they all be instrument/mic inputs?

Thanks

boss sp-303 to isa 428 - use line or instrument inputs?

hello everyone, i'm just here late at night trying to break in my isa 428, and i have a question. actually, this really has nothing to do with the 428 per se, but rather how to run line outs from a sampler/mixer. When i used to use my PreSonus firestation, i would run the line outs of my boss sp-303 or Korg ms2000b into the line ins of the firestation.

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