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Mackie Bus or Pro Tools Bus?

I know this way somewhat discussed in another thread, but not exactly. What do you guys think would be better quality? 32 tracks to 16 PT bused D/A via AD8000 to a Mackie, or 32 individual D/A channels (no PT bus) of 888 to a Mackie? What I am trying to figure out is at what point does the busing on Pro Tools start to mess with the sound.

stop me before I blow something up. .

If I needed to achieve an extremely compressed bass guitar sound, and I only have a Joemeek SC2.2 stereo compressor available - is it possible to run through both channels in series? Can I come out of my mic preamp into the left channel input on the Meek, out of the left channel output, into the right channel input and finally out of the right channel output back to the console?