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Tweaking Tuning on on a guitar or studio instrument - limits of what can be done?

I cut a lead improv over a bass track & rhythm track I laid down and ended up being surprised with the result (enough not to delete). There's a couple areas where there's some tuning anomalies - partly due to the fact the guitar was a fully floating Floyd Rose that I hadn't locked into hardtail mode and that I cut this at the end of a rather long playing session.

Proper place to insert guitar effects in DAW

Hello, sorry if this isn't the right category for my question.

I have a track with the dry signal out of recorded guitar and I'm using a virtual amp head with an impulse as a cabinet.
My question is what is the proper place to use any effect plugins (reverb, delay etc), as insert or send effects?